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Glass Joe is the initial opponent that Little Mac must face. He is considerably inferior to Mac and possesses the game's most fragile jaw. Glass Joe can be employed as a training aid to refine your evasion and striking counterattack techniques.
Don Flamenco, a Spanish charmer, is Little Mac's first adversary in the Major circuit. He possesses an eccentric personality and intentionally taunts you until you make the first move. Once you initiate an attack, he responds with a powerful uppercut, which becomes manageable to evade with practice. If you can master the timing, Don Flamenco is the quickest opponent you can knock out.
As a novice player, Bald Bull can be an extremely daunting opponent in the game, causing you a lot of frustration. It took me a long time to finally overcome him, and I remember struggling with the timing of his Bull Charge move, which made me throw my controllers in frustration. However, I have a helpful suggestion - pay attention to the crowd's reaction when he begins to charge at you, as there is a visual cue that can assist you in throwing the perfect punch to defeat him.
Little Mac encounters a familiar adversary in the 10th fight, the formidable Bald Bull. Among the boxers featured in the NES edition of Mike Tyson’s Punch-Out, he is considered one of the most challenging to conquer. This iteration of Bald Bull can be an incredibly frustrating match and require a great deal of patience to defeat. One can only overcome him by expertly countering his Bull Charge or executing a precisely-timed uppercut.
The penultimate challenge in Mike Tyson's Punch-Out brings us face to face with Macho Man. The first encounter with him is an enlightening experience, as he proves to be significantly more difficult to defeat than Soda Popinski despite sharing some of his moves. He boasts a remarkably fast uppercut and a devastating spinning "Macho Punch" that can send you flying into oblivion. It's essential not to be distracted by his pec muscles bouncing as he dances in the ring.
Von Kaiser, the German fighter, is the second challenger that Little Mac encounters, and similar to Glass Joe, he presents minimal opposition. Von Kaiser's knee-knocking stance can pose a challenge for novice players who have not yet perfected their dodging techniques. However, as you gain mastery of the game, he will soon become an easy target.
King Hippo is one of my preferred characters in the game and unquestionably the most comical. He is characterized by his voluminous mouth, paunch, and shorts. The key to defeating him is targeting his shorts with a precise punch that will cause them to drop to the ground. When he reaches down to pull them back up, Little Mac can seize the opportunity to finish him off. Diehard fans of the game will appreciate the reference to the X mark on King Hippo's belly, which denotes his weak spot.
Piston Honda makes a comeback in the Major Circuit to challenge Little Mac once again. This time, he has enhanced his defensive skills and become significantly more aggressive.
The upcoming fight features a rematch with Don Flamenco, the flamboyant Spanish boxer known for his dancing moves. This time, he proves to be quite vexing as his defense has significantly improved. Although he can drag out the match to two rounds, he is not considered a particularly daunting opponent in the world circuit.
If you've reached this point, congratulations are in order - you've completed the gauntlet and are now ready to face the most ferocious boxer in the game, the legendary Mike Tyson. He is the most challenging character to defeat due to his ability to knock out opponents with every punch. Facing him for the first time can be an incredibly nerve-wracking experience, and it may take multiple attempts - 5, 10, or even 20+ - to figure out how to defeat him.
The initial significant obstacle for Little Mac arises during his first encounter with Piston Honda, whose punches pack a considerable punch, particularly his uppercuts. Piston Honda's signature jab sequence, the Honda Rush, is a potent combination that can result in defeat if he successfully lands it.
The Great Tiger poses a significant challenge on the Major circuit, and it requires practice to overcome him. He executes a swift left counter jab that is difficult to evade, and his teleport punch can be daunting during the initial confrontation. The key to defeating him is to observe his turban, which indicates the direction of his punches.
The second match of the world circuit poses a significant challenge in the form of Soda Popinski, previously known as Vodka Drunkenski. He is a massive character who boasts a notorious evil laugh, which he uses to intimidate his opponents during the bout. While he can be defeated with swift dodges and punches, one must be cautious since his attacks can inflict significant damage on your health if they land.
Now we come to the most renowned characters in Tyson's Punch-Out, the crème de la crème. The first of these is the Sandman, whose intimidating appearance is one of the most formidable in the game. He possesses a wide range of offensive moves, including rolling jabs and incredibly fast and powerful uppercuts referred to as the Dreamland Express. Defeating him in the early stages of the game is a significant challenge.