The Tiger-Cats are a CFL team from Hamilton, Ontario, Canada, playing in the East Division. Their home games are held at Tim Hortons Field. They got their name after merging with the Hamilton Wildcats in 1950.

Les Alouettes de Montréal is a CFL team from Quebec, Canada, founded in 1946 and revived twice. They compete in the East Division of the CFL, last winning the Grey Cup in 2010. Their regular-season games are played at Percival Molson Memorial Stadium, which has also hosted their playoff games since 2014.

The Redblacks, a CFL team from Ottawa, Ontario, play in the East Division. They are the third CFL team to play in Ottawa, following the Rough Riders, founded in 1876, and the Renegades, founded in 2002 but lasting only until the end of the 2005 season. The Redblacks won the 2016 Grey Cup Championship, breaking a 40-year championship drought for the city.

The Argos, a CFL team from Toronto, Ontario, play in the East Division. Founded in 1873, they are North America's oldest existing professional sports team still using their original name, and the oldest-surviving team in the modern-day CFL and East Division. The team's origins go back to a modified form of rugby football that emerged in North America in the late 19th century. After playing at Rogers Centre from 1989 to 2016, the Argonauts moved to BMO Field, their fifth stadium site.

The BC Lions are a CFL team from Vancouver, British Columbia, playing in the West Division. Their home games are held at BC Place. Founded in 1954, they have played every season since, making them the oldest professional sports franchise in British Columbia. They have won six Grey Cup championship games out of the ten appearances, with the most recent one in 2011.

The Stampeders, a CFL team from Calgary, Alberta, play in the West Division and their home games are held at McMahon Stadium. They are the third-oldest active franchise in the CFL, founded in 1945, with earlier clubs operating in Calgary since the 1890s.

The Elks are a CFL team based in Edmonton, Alberta, playing in the West Division at the Brick Field at Commonwealth Stadium. They were founded in 1949 under the name Edmonton Eskimos, and have won the Grey Cup championship 14 times, including a three-peat between 1954 and 1956 and five consecutive wins between 1978 and 1982. The team has a rivalry with the Calgary Stampeders and is one of three community-owned teams in the CFL. In 2020, the team discontinued using the "Eskimos" name and officially announced the new name "Elks" on June 1, 2021.

The Saskatchewan Roughriders are a Canadian football team based in Regina, Saskatchewan, and compete in the Canadian Football League (CFL) as a member of the league's West Division. Founded in 1910 as the Regina Rugby Club, they are one of the oldest professional sports teams in North America and the fourth-oldest professional gridiron football team still in existence. The team has an unbroken organizational continuity since their founding, making them the oldest surviving team in the CFL's present-day West Division. The Roughriders have played their home games at Mosaic Stadium at Evraz Place since 2017, having previously played at Taylor Field from 1936 to 2016.

The Winnipeg Blue Bombers is a Canadian football team playing in the CFL's West division and based in Winnipeg, Manitoba. The team's home games are held at IG Field. Founded in 1930 as the Winnipeg Rugby Football Club, later known as the Winnipeg Football Club, they are one of three community-owned teams in the league.