One of the renowned ex-private investigators in Port Charles is Curtis Ashford, who currently owns The Savoy, a famous nightclub and music venue. Curtis has recently reconciled with his father, Marshall Ashford, and has close family connections with his Aunt Stella Henry and nephew T.J. Ashford.

The Port Charles Police Department is led by Jordan Ashford, who became the Commissioner in 2014. Prior to joining the PCPD, she worked as an undercover DEA agent. Jordan is a mother to a son named T.J. Ashford.

Marshall Ashford, who is Curtis Ashford's father and was once estranged from him, is a passionate musician. Previously assumed to be deceased, he has now reappeared in Port Charles and is resolute in his efforts to mend his relationship with his son.

T.J. Ashford, a promising figure at General Hospital, is the offspring of Jordan Ashford and Shawn Butler. He was named after Tommy Ashford, the man believed to be his father. T.J.'s family has expanded to include his grandfather, Marshall Ashford, and his partner, Molly Lansing-Davis.

Dante Falconeri's longtime friend, Cody Bell, was a mystery to many until he disclosed his identity as Dominique Stanton's son and Serena Baldwin's half-brother, and a stuntman by profession.

Port Charles' Drew Cain is the offspring of Alan Quartermaine and the twin brother of the deceased Jason Morgan. Drew has two children, Emily "Scout" Cain and the late Oscar Nero. Following an assassination attempt by Peter August, he returned to Port Charles in 2020.

The offspring of Nikolas Cassadine and the late Courtney Matthews is Spencer Cassadine, whose family includes Laura Collins as his grandmother, Sonny Corinthos as his uncle, and Cameron Webber as his cousin. Spencer spent a considerable part of his youth in European boarding schools before returning to Port Charles recently.

Ivan Cassadine's son and Mikkos Cassadine's late brother is Victor Cassadine, who has feigned his own demise on numerous occasions, with the latest being caused by Liesl Obrecht and an explosion at the Crichton-Clark Clinic. Upon his most recent return, Victor disclosed that he is Valentin Cassadine's biological father.

The father of both Harrison Chase and Hamilton Finn is Gregory Chase, who works as a professor at the University of Berkeley. Gregory and his wife, Jackie Templeton, have recently split up.

Harrison Chase is a Port Charles Police Department detective and the half-sibling of Dr. Hamilton Finn. His adherence to the rules has earned him a reputation as the department's most fastidious officer.

Laura Collins is among Port Charles' most legendary inhabitants, with a storied past that includes marrying Luke Spencer, fighting false murder allegations, combating the Cassadines, and emerging as the city's newest Mayor. Laura has three children: Lucky Spencer, Lulu Spencer-Falconeri, and Nikolas Cassadine. Her six grandchildren are Charlotte Cassadine, Spencer Cassadine, Rocco Falconeri, Cameron Webber, Jake Webber, and Aiden Webber.

He is the offspring of A.J. Quartermaine, who has since passed away, and his former spouse Carly Benson. Additionally, he was adopted by the notorious mob leader Sonny Corinthos. It's worth noting that he was conceived from a brief encounter between two individuals with a strong mutual animosity.

Known as the Godfather of Port Charles, Sonny Corinthos is the proprietor of Corinthos Coffee and a self-described "businessman." He has five children who are currently alive: Dante Falconeri, Michael Corinthos, Kristina Davis, Avery Corinthos, and Donna Corinthos. Tragically, his son Morgan passed away in 2018.

Having been born to Mikkos Cassadine, Alexis Davis was once among Port Charles' most influential lawyers. She cherishes her role as a mother, having raised three daughters: Sam McCall, Molly Lansing-Davis, and Kristina Davis.

Anna Devane has been an operative for the WSB (World Security Bureau) for over 40 years, operating as a spy. She first appeared in Port Charles in 1985, and subsequently married prominent residents Duke Lavery and Robert Scorpio. Additionally, Anna is the mother of Robin Scorpio-Drake.

The progeny of Sonny Corinthos, a notorious mob leader, and Olivia Quartermaine, Dante Falconeri is presently employed as a Detective at the Port Charles Police Department. He and Lulu Spencer, his former spouse, have one son, Rocco Falconeri, together.

An expert in infectious diseases, Dr. Hamilton Finn came to Port Charles in 2016. He gained widespread acclaim for his successful treatment of Blackwoods Syndrome and utilized the proceeds to rescue General Hospital from financial ruin. Finn's familial connections encompass his half-brother, Harrison Chase, who serves as a detective for the PCPD, as well as his daughter Violet and pet bearded dragon named Roxy.

Born to Jimmy Lee Holt and Charity Gatlin, Dr. Austin Gatlin-Holt arrived in Port Charles with the intention of contesting his grandfather Edward Quartermaine's will and asserting his rightful ownership of the ELQ shares that were denied to his father. However, when Brook Lynn Quartermaine threatened to expose his secrets, he ultimately decided to prioritize his medical profession over his claim to the Quartermaine legacy.

Sasha Gilmore was initially persuaded by Valentin Cassadine to deceive his estranged spouse (Nina Reeves) in order to rekindle their romance. Despite this, she ended up co-owning Deception Cosmetics with long-time Port Charles resident Lucy Coe.

Dex Heller is a veteran who served in Afghanistan and was discharged following an altercation with a superior officer. He was hired by Michael Corinthos to gather evidence against Sonny's organization. While working for Sonny, he met Josslyn Jacks and the two became involved after he asked for her help when he was shot. They helped each other when Josslyn was attacked by Heather Webber, also known as the Hook. Dex is estranged from his own family and has made references to having brothers, but it is unclear if this is true.

Josslyn Jacks is the offspring of Jasper Jacks and Carly Corinthos. She has half-siblings in Michael and Donna Corinthos, step-siblings in Kristina Corinthos-Davis, Dante Falconeri, and Avery Corinthos. Josslyn survived a battle with cancer at a young age, aided by a kidney transplant from the now-deceased Nelle Benson.

The proprietor of Port Charles' most prominent art gallery is Ava Jerome, who shares a lineage with her deceased sibling Julian Jerome as the offspring of notorious crime kingpin Victor Jerome. Additionally, Ava is a mother of two: Avery Corinthos and the now-deceased Kiki Jerome.

Maxie Jones, daughter of Frisco Jones and Felicia Scorpio, was primarily raised by her stepfather, Mac Scorpio. She is a mother to three children: Georgie Jones-Spinelli, James West, and Bailey Louise Jones. While she shares custody of Georgie with Damian Spinelli, James' father Nathan West passed away before his birth. The father of Bailey, Peter August, is a well-known criminal.

Sam McCall, daughter of Alexis Davis and Julian Jerome, works as a private investigator and is recognized for her daring personality. She is a mother to two children: Danny Morgan and Emily "Scout" Cain.

Esme Prince is a mysterious individual who attended boarding school with Spencer Cassadine in France before arriving in Port Charles. She assisted Spencer in trying to break up his father Nikolas and Ava Jerome, and appears to have a disturbing fascination with Ryan Chamberlain, who is currently in prison.

Brook Lynn Quartermaine, previously known as Brook Lynn Ashton, is the daughter of Lois Cerullo and Ned Quartermaine. Similar to her grandmother Tracy Quartermaine, Brook Lynn is a vocal member of the Quartermaine family and is pursuing a career as a singer/songwriter.

Nina Reeves is the Editor-in-Chief of Crimson, a renowned fashion magazine. She was raised by her adopted brother, Nathan West, and is the biological daughter of Madeline Reeves. Although she was unable to form a relationship with her daughter, the late Nelle Benson, Nina is determined to be there for her grandson, Wiley Corinthos.

General Hospital employee Dr. Portia Robinson is the ex-spouse of Marcus Taggert and mother of Trina Robinson. She played a key role in bringing Cyrus Renault to justice.

Currently a student at Port Charles University, Trina Robinson is the daughter of Dr. Portia Robinson and Lt. Marcus Taggert, and a close friend of Josslyn Jacks and Cameron Webber.

Felicia Scorpio, previously known as Felicia Jones, has a rich history in Port Charles. She had two daughters with her ex-husband Frisco Jones, Maxie Jones and the late Georgie Jones. Alongside her current husband, Mac Scorpio, Felicia co-owned The Floating Rib, which unfortunately was destroyed in 2020.

Carly, a member of the Spencer family, is the daughter of Bobbie and the niece of Luke. She arrived in Port Charles in 1996 and worked her way up from a rented room to the top of society. After her recent divorce from mob boss Sonny Corinthos, Carly is focused on rebuilding her life independently. She shares custody of her youngest child, Donna Corinthos, with Sonny. Carly's adult children, Michael Corinthos and Josslyn Jacks, are equally passionate as their mother. Carly's relationship with Drew Cain has evolved from friendship to something more.

Willow Tait gave birth to a baby boy who was adopted by Brad Cooper and Lucas Jones, but tragically died. Brad then swapped him with Jonah Corinthos, the son of Michael Corinthos and Nelle Benson. Willow and Michael got married briefly and now plan to raise Jonah, who has been renamed Wiley Corinthos, together.

Elizabeth Webber is a renowned nurse at General Hospital and the granddaughter of the esteemed Chief of Staff Steve Hardy and his wife Audrey. She arrived in Port Charles as a teenager and has become a beloved member of the community. Elizabeth has three sons, namely Cameron, Jake, and Aiden Webber.